Alexander, Robert L., Sile O’Modhrain, D. Aaron Roberts, Jason A. Gilbert, and Thomas H. Zurbuchen. “The Bird’s Ear View of Space Physics: Audification as a Tool for the Spectral Analysis of Time Series Data.” Journal of Geophysical Research: Space Physics 119, no. 7 (2014): 5259–71. https://doi.org/10.1002/2014JA020025
The Evans Old Field Plant Database contains FileMaker and Excel files of data collected by Dr. Francis C. Evans during a 50-year study on successional change on Evans Old Field on the Edwin S. George Reserve. Data include plant phenology, location, and abundances observed from 1948 to 1997.
Supporting Information for research article "Life cycle comparison of environmental emissions from three disposal options for unused pharmaceutical". This spreadsheet provides the calculations and values used for this study; please refer to the manuscript and supporting information (as text) available at http://dx.doi.org/10.1021/es203987b for details about how to use this spreadsheet. We use life cycle assessment methodology to compare three disposal options for unused pharmaceuticals: (i) incineration after take-back to a pharmacy, (ii) wastewater treatment after toilet disposal, and (iii) landfilling or incineration after trash disposal. For each option, emissions of active pharmaceutical ingredients to the environment (API emissions) are estimated along with nine other types of emissions to air and water (non-API emissions). Under a scenario with 50% take-back to a pharmacy and 50% trash disposal, current API emissions are expected to be reduced by 93%. This is within 6% of a 100% trash disposal scenario, which achieves an 88% reduction. The 50% take-back scenario achieves a modest reduction in API emissions over a 100% trash scenario while increasing most non-API emissions by over 300%. If the 50% of unused pharmaceuticals not taken-back are toileted instead of trashed, all emissions increase relative to 100% trash disposal. Evidence suggests that 50% participation in take-back programs could be an upper bound. As a result, we recommend trash disposal for unused pharmaceuticals. A 100% trash disposal program would have similar API emissions to a take-back program with 50% participation, while also having significantly lower non-API emissions, lower financial costs, higher convenience, and higher compliance rates.
Citation to related publication:
Cook, Sherri M., Bryan J. VanDuinen, Nancy G. Love, and Steven J. Skerlos. “Life Cycle Comparison of Environmental Emissions from Three Disposal Options for Unused Pharmaceuticals.” Environmental Science & Technology 46, no. 10 (May 15, 2012): 5535–41. https://doi.org/10.1021/es203987b
Scientists often try to reproduce observations with a model, helping them explain the observations by adjusting known and controllable features within the model. They then use a large variety of metrics for assessing the ability of a model to reproduce the observations. One such metric is called the relative operating characteristic (ROC) curve, a tool that assesses a model’s ability to predict events within the data. The ROC curve is made by sliding the event-definition threshold in the model output, calculating certain metrics and making a graph of the results. Here, a new model assessment tool is introduced, called the sliding threshold of observation for numeric evaluation (STONE) curve. The STONE curve is created by sliding the event definition threshold not only for the model output but also simultaneously for the data values. This is applicable when the model output is trying to reproduce the exact values of a particular data set. While the ROC curve is still a highly valuable tool for optimizing the prediction of known and pre-classified events, it is argued here that the STONE curve is better for assessing model prediction of a continuous-valued data set.
and Data and code were created using IDL, but can also be accessed with the open-source Gnu Data Language (GDL; see https://github.com/gnudatalanguage/gdl)
Liemohn, M. W., Azari, A. R., Ganushkina, N. Yu., & Rastätter, L. (2020). The STONE curve: A ROC-derived model performance assessment tool. Earth and Space Science, 7, e2020EA001106. https://doi.org/10.2019/2020EA001106
The editorial decision process for the Journal of Geophysics Research Space Physics is assisted by over 1,000 scientists every year, providing over 3,000 reviews per year. These statistics are presented for the years 2013 through 2018, showing some fluctuations but, overall, consistency in the response of the space physics research community to requests to serve as manuscript reviewers. Over half of these reviews are submitted on time, and the average time to review actually dropped as the load increased. This is greatly appreciated and the community is to be commended and thanked for their willingness to help make this journal thrive and remain a premiere publication in the field.
Transcriptional accessibility of chromatin is central to guiding CD4+ T cell function through regulation of lineage specific gene expression. Myst1 is a histone acetyltransferase responsible for acetylation of the protein tail of histone 4 at lysine residue 16 (H416ac), resulting in increased transcriptional accessibility and activation of gene transcription. Previous studies have described a role for Myst1 in governing lymphocyte development in the thymus, however the role of Myst1 and H4K16ac in guiding activation of peripheral CD4+ T cells has not been studied. Activation of human and murine CD4+ T cells resulted in upregulation of Myst1 expression, and deletion of Myst1 resulted in changes in proliferative responses to both polyclonal stimulus and exogenous cytokines. Myst1-deficient T cells also exhibited modulations in lineage commitment, with decreased function in TH1/TH2 skewing conditions and increased function in response to TH17-promoting conditions. Regulation of Myst1 function in CD4+ T cells appears governed at least in part by STAT5, as Myst1 expression is regulated by STAT5 expression and DNA binding, and modulations in H4K16ac in Myst1-deficient CD4+ T cells is observable at sites in the promoter regions of lineage specific genes following skewing to the TH1 or TH2 lineage in vitro. Taken together, these results indicate an important role for the STAT5-Myst1 epigenetic axis in governing the activation and effector function of CD4+ T cells.
Raw data and analysis files for the figures corresponding to the manuscript submission entitled "CCL2 enhances macrophage inflammatory responses via miR-9 mediated downregulation of the ERK1/2 phosphatase Dusp6"
Estimated phylogenetic relationships based on more than 18,000 loci in 93 individuals (full data) or 21 individuals (subset data) representing 19 described species and two putative undescribed species. Nine files are part of this dataset, including all input files to infer the phylogenetic reconstructions and the outputs obtained, in addition to a pruned tree used to infer the ancestral state reconstructions.
Andréa T. Thomaz, Tiago P. Carvalho, Luiz R. Malabarba, L. Lacey Knowles, Geographic distributions, phenotypes, and phylogenetic relationships of Phalloceros (Cyprinodontiformes: Poeciliidae): insights about diversification among sympatric species pools, Molecular Phylogenetics and Evolution, 2018, ISSN 1055-7903, https://doi.org/10.1016/j.ympev.2018.12.008