Now showing items 161-170 of 172
Uncovering Hidden Dynamics in Living Systems Using Bayesian Statistics and Single-Molecule Microscopy
(2019)
Fluorescence microscopy is a powerful technique for understanding the organization, structure and dynamics of cells. Single-molecule imaging techniques extend our ability to probe cellular systems down to a range of only ...
Direct Identification and Counting of MicroRNAs in Single Cells by Transient Binding and Kinetic Fingerprinting
(2023)
Cancer is the second leading cause of mortality worldwide. Within the U.S. alone, it is estimated that 1.9 million people will be diagnosed this year and over 610,000 people are expected to perish. Despite advances in ...
Computational Methods for Understanding Dynamics in Mass Transport and Tissue Development
(2020)
Elucidating the process by which a biological system evolves and properly identifying hidden states and influential underlying factors are important for studying biological functions and origins of diseases. However, due ...
Development and Application of Numerical Methods in Biomolecular Solvation
(2021)
This work addresses the development of fast summation methods for long range particle interactions and their application to problems in biomolecular solvation, which describes the interaction of proteins or other biomolecules ...
Investigation of Membrane Order Within Integrin-Mediated Adhesion
(2018)
Integrins are transmembrane adhesion receptors that engage ligands in the extracellular matrix and cytoskeletal proteins to form multi-protein adhesive complexes. These complexes provide a platform for integrin signaling ...
Interactions Between Fluorescent Molecules and Plasmonic Nanoparticles: A Super-Resolution Study
(2017)
Single-molecule super-resolution imaging techniques play an increasingly important role in studying complex fine structures, dynamics and interactions in nanoscale confined spaces. The resolution of this technique can be ...
Exploring Drug Bioaccumulation and Stabilization with Respect to Endolysosomal Ion Homeostasis Using a Systems-Based Mathematical Modeling Approach
(2018)
Even though most of the FDA approved drugs currently out in the market and in the process of development are weakly basic drugs, the bioaccumulation and stabilization of these drugs are not well understood. For this purpose, ...
Disruption of Model Membranes by PAMAM Dendrimers and Quantitative Nanoscale Analysis of Type I Collagen.
(2010)
erionic DPPC in the gel phase. Generation 5 and 7 Poly(amidoamine) dendrimers preferentially disrupt the fluid layer. For the first time, dendrimer can be observed collecting on top of the lipid preceding removal. The ...
Hsp70 chaperone Proteins and their Interactions with Various Drugs as Studied by Nuclear Magnetic Resonance.
(2011)
Chaperone proteins and their cochaperones are perhaps one of the most intriguing systems for investigation. Ubiquitous in nature, they can be found in every organism and that perhaps is the reason that their sequence shows ...
Molecular Dynamics Simulation of Phase and Structural Transitions in Model Lung Surfactant Mixtures.
(2010)
Lung surfactant (LS) is a complex mixture of lipids and proteins that reduces and regulates the surface tension in the lungs, thereby decreasing the work of breathing. A thorough understanding of LS function is critical ...