Now showing items 7591-7600 of 7606
Intergenerational arsenic exposure on the mouse epigenome and metabolic physiology
(John Wiley & Sons, Inc., 2023-02)
Inorganic arsenic (iAs) is one of the largest toxic exposures to impact humanity worldwide. Exposure to iAs during pregnancy may disrupt the proper remodeling of the epigenome of F1 developing offspring and potentially ...
The local health impacts of natural resource booms
(Wiley Periodicals, Inc.World Bank, 2023-02)
This paper uses novel micro-data on natural resources and administrative health data in Brazil to study how economic booms in minerals affect health at birth. By implementing a reduced-form estimation of shift-share research ...
Super-Strong Hydrogel Composites Reinforced with PBO Nanofibers for Cartilage Replacement
(Wiley Periodicals, Inc.Imperial College Press, 2023-02)
Cartilage replacement materials exhibiting a set of demanding properties such as high water content, high mechanical stiffness, low friction, and excellent biocompatibility are quite difficult to achieve. Here, ...
Loss of oligodendrocyte ErbB receptor signaling leads to hypomyelination, reduced density of parvalbumin-expressing interneurons, and inhibitory function in the auditory cortex
(John Wiley & Sons, Inc., 2023-02)
For a long time, myelin was thought to be restricted to excitatory neurons, and studies on dysmyelination focused primarily on excitatory cells. Recent evidence showed that axons of inhibitory neurons in the neocortex are ...
Robust causal inference of drug-drug interactions
(John Wiley & Sons, Inc., 2023-03-30)
Engineering Multifunctional Nanoparticles: Applied Nanoscale Therapeutics
(2022)
Decades of research towards the development of nanomedicines have, to date, yielded minimal
clinical impact. Focused particularly on the treatment of cancer, the relatively low
number of pursued technologies to reach the ...
Targeting MCL-1 and BCL-2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non-Hodgkin lymphoma: Results from preclinical models and a Phase Ib study
(John Wiley & Sons, Inc., 2023-03)
The treatment of patients with relapsed or refractory lymphoid neoplasms represents a significant clinical challenge. Here, we identify the pro-survival BCL-2 protein family member MCL-1 as a resistance factor for the BCL-2 ...
Development and Validation of Transportable, Clinically Applicable and Scalable Machine Learning Models for Acute Kidney Injury
(2024)
Acute kidney injury (AKI), a frequent complication in hospitalized patients, poses significant challenges due to its high incidence, short-term mortality, and substantial economic burden. Current AKI models utilizing ...
Auditory Cortical Ensemble-Mechanisms Facilitating Auditory-Driven Behaviors and Perception
(2023)
Sounds in our everyday environment play a crucial role in guiding our perception and behaviors. The ability to effectively process these sounds—perceive them, contextualize their meaning, and subsequently harness this ...
The Public Health Consequences of Compounding Disasters and Colonialism in Puerto Rico: A Mixed-Methods Investigation
(2024)
In recent decades, the ongoing climate crisis has disproportionately impacted historically marginalized populations globally through environmental hazards and disasters. Understanding the health impacts of multiple disaster ...