Search Constraints
Number of results to display per page
View results as:
Search Results
-
- Creator:
- Lee, Kyu Han, Foxman, Betsy, and Gordon, Aubree
- Description:
- Data include variables used to run mixed effects models examining the association between the nose/throat microbiome and influenza virus infection. Certain individual participant data have been excluded due to identifiability concerns. Data also include the oligotype count table and taxonomic classifications. and Curation Notes: Readme updated Nov. 29, 2018 with context for oligotype and taxonomy files, and citation to associated article.
- Keyword:
- Influenza and Microbiome
- Citation to related publication:
- Lee KH, Gordon A, Shedden K, Kuan G, Ng S, Balmaseda A, Foxman B. The respiratory microbiome and susceptibility to influenza virus infection. PloS One. 2019;14:e0207898. https://doi.org/10.1371/journal.pone.0207898
- Discipline:
- Health Sciences
-
- Creator:
- Kort, EA, Gvakharia, A, Smith, ML, and Conley, S
- Description:
- Data is collected from research flights based in West Memphis, Arkansas, covering the Mississippi River Valley. The data file contains all merged flight data from each flight day.
- Keyword:
- Greenhouse gas
- Citation to related publication:
- Gvakharia, A., Kort, E.A., Smith, M.L., Conley, S., 2018. Testing and evaluation of a new airborne system for continuous N2O, CO2, CO, and H2O measurements: the Frequent Calibration High-performance Airborne Observation System (FCHAOS). Atmospheric Measurement Techniques; Katlenburg-Lindau 11, 6059. https://doi.org/10.5194/amt-11-6059-2018
- Discipline:
- Science
-
- Creator:
- Liemohn, Michael W, McCollough, James P, Engel, Miles A, Jordanova, Vania K, and Morley, Steven K
- Description:
- There is a directory tree inside this zipped file. The main directory has the Adobe Illustrator plots of the figures in the paper, Space Weather journal manuscript # 2018SW002067, "Model evaluation guidelines for geomagnetic index predictions" by M. W. Liemohn and coauthors. The three subdirectories have the files for the individual models, the data to which they are compared, and the IDL code used to create the figure plots and metrics calculations. and Date coverage is specific to each model. The RAMSCB model covers January 2005, the WINDMI model all of 2014, and the UPOS model 1.5 solar cycles, from 1 October 2001 through 29 July 2013.
- Keyword:
- space weather, model assessment, time series metrics, and geomagnetic indices
- Discipline:
- Science
-
- Creator:
- Adams, Julia
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication https://doi.org/10.3998/mpub.10079890, and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a - https://doi.org/10.3998/mpub.10079890.cmp.1 to the publication.
- Keyword:
- eportfolio , gateway, sitesucker, website, and file directory
- Citation to related publication:
- Gere, A.R., Editor. Developing Writers in Higher Education: A Longitudinal Study, fulcrum.org. University of Michigan Press. https://doi.org/10.3998/mpub.10079890
- Discipline:
- Humanities
-
- Creator:
- R Paul Drake
- Description:
- The specific focus of the project was radiative shocks, which develop when shock waves become so fast and hot that the radiation from the shocked matter dominates the energy transport. This in turn leads to changes in the shock structure. Radiative shocks are challenging to simulate, as they include phenomena on a range of spatial and temporal scales and involve two types of nonlinear physics Ð- hydrodynamics and radiation transport. Even so, the range of physics involved is narrow enough that one can hope to model all of it with sufficient fidelity to reproduce the data. CRASH was focused on developing predictions for a sequence of experiments performed in Project Year 5, in which those experiments represented an extrapolation from all previously available data. The previous data involved driving radiative shocks within cylindrical structures, and mainly straight tubes. The Year 5 experiments drove a radiative shock down an elliptical tube. Our long-stated goal for these predictions was that the distribution of predicted values would overlap significantly with the observed distribution. We achieved this goal. Achieving our goal required the conversion of an established space-weather code to model radiative shocks at high energy density. To obtain reasonable fidelity with respect to the experimental data required implementing a laser absorption package, in addition to a hydrodynamic solver, electron physics and heat conduction, and multigroup diffusive radiation transport. The dedicated experiments provided evidence of experimental variability, validation of the calculation of initial shock wave behavior, and validation data at many observation times using cylindrical shock tubes. Following this were preparatory experiments for and finally the execution of the Year 5 experiments. The predictive science research included a wide range of sensitivity studies to determine which variables were important and a sequence of predictive studies focused on specific issues and sets of data. This led ultimately to predictions of shock location for the Year 5 experiments. A conclusion from this project is that the serious quantification of uncertainty in simulations is a dauntingly difficult and expensive prospect. Pre-existing codes are unlikely to have been built with attention to what will be needed to quantify their uncertainty. Pre-existing experimental results are even more unlikely to include a sufficiently detailed analysis of the experimental uncertainties. And this will also be true of most experiments that might be used to validate components of the simulation. The analysis of uncertainty in any one of the physical processes (and related physical constants) is a major effort. And addressing model form uncertainty is an even bigger challenge, that may in principle require development of complete, alternative simulation models. We made a start at all of this, and completed almost none of it. But by the end of a project, we finally had all the pieces in place and working that would have enabled a range of important studies and advances in relatively near-term years. But the sponsor terminated the program after only five years. For most of the participants this was a relatively minor development, although for a few of them it proved to be enormously disruptive. We believe that the cost to the nation, in work that was ready be done but now will not be, was much much larger. The sketch of the target was produced using a drawing program based on the experimental dimensions. The annotated photograph of the target was obtained using a visible-light camera. The colorized radiographs were obtained via backilit-pinhole radiography of a radiative shock propagating down an elliptical tube, at 26 ns after the lasers driving the shock tube fired. The graph showing lines and circles was produced by running many computer models, analyzing their statistical distribution, and measuring actual shock positions in the experiment.
- Keyword:
- Radiative shock
- Discipline:
- Science
-
- Creator:
- Ramasubramani, Vyas
- Description:
- The goal of the work is to elucidate the stability of a complex experimentally observed structure of proteins. We found that supercharged GFP molecules spontaneously assemble into a complex 16-mer structure that we term a protomer, and that under the right conditions an even larger assembly is observed. The protomer structure is very well defined, and we performed simulations to try and understand the mechanics underlying its behavior. In particular, we focused on understanding the role of electrostatics in this system and how varying salt concentrations would alter the stability of the structure, with the ultimate goal of predicting the effects of various mutations on the stability of the structure. There are two separate projects included in this repository, but the two are closely linked. One, the candidate_structures folder, contains the atomistic outputs used to generate coarse-grained configurations. The actual coarse-grained simulations are in the rigid_protein folder, which pulls the atomistic coordinates from the other folder. All data is managed by signac and lives in the workspace directories, which contain various folders corresponding to different parameter combinations. The parameters associated with a given folder are stored in the signac_statepoint.json files within each subdirectory. The atomistic data uses experimentally determined protein structures as a starting point; all of these are stored in the ConfigFiles folder. The primary output is the topology files generated from the PDBs by GROMACS; these topologies are then used to parametrize the Monte Carlo simulations. In some cases, atomistic simulations were actually run as well, and the outputs are stored alongside the topology files. In the rigid_protein folder, the ConfigFiles folder contains MSMS, the software used to generate polyhedral representations of proteins from the PDBs in the candidate_structures folder. All of the actual polyhedral structures are also stored in the ConfigFiles folder. The actual simulation trajectories are stored as general simulation data (GSD) files within each subdirectory of the workspace, along with a single .pos file that contains the shape definition of the (nonconvex) polyhedron used to represent a protein. The logged quantities, such as energies and MC move sizes, are stored in .log files. The logic for the simulations in the candidate_structures project is in the Python scripts project.py, operations.py, and scripts/init.py. The rigid_protein folder also includes the notebooks directory, which contains Jupyter notebooks used to perform analyses, as well as the Python scripts used to actually perform the simulations and manage the data space. In particular, the project.py, operations.py and scripts/init.py scripts contain most of the logic associated with the simulations.
- Keyword:
- Protein assembly, Cryo TEM, Hierarchical Assembly, Monte Carlo simulation, and Coarse-grained simulation
- Discipline:
- Science and Engineering
-
- Creator:
- Avesian, Erica
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , capstone, sitesucker, website , and file directory
- Discipline:
- Humanities
-
- Creator:
- Lisner, Emily
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , gateway , sitesucker , website , and file directory
- Citation to related publication:
- GERE, A. R. (Ed.). (2019). DEVELOPING WRITERS IN HIGHER EDUCATION: A longitudinal study. S.l.: UNIV OF MICHIGAN PRESS. https://doi.org/10.3998/mpub.10079890
- Discipline:
- Humanities
-
- Creator:
- Garno, Gregory
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , gateway , sitesucker, website , and file directory
- Discipline:
- Humanities
-
- Creator:
- Adams, Julia
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , gateway , sitesucker , website , and file directory
- Discipline:
- Humanities
-
- Creator:
- Brown, Kathryn
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , capstone , sitesucker , website , and file directory
- Citation to related publication:
- GERE, A. R. (Ed.). (2019). DEVELOPING WRITERS IN HIGHER EDUCATION: A longitudinal study. S.l.: UNIV OF MICHIGAN PRESS. https://doi.org/10.3998/mpub.10079890
- Discipline:
- Humanities
-
- Creator:
- Brown, Kathryn
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , gateway , sitesucker , website, and file directory
- Discipline:
- Humanities
-
- Creator:
- Cockrum, Kayla
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , capstone , sitesucker , website , and file directory
- Discipline:
- Humanities
-
- Creator:
- Schuler, Kaitlin
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , gateway , sitesucker , website , and file directory
- Citation to related publication:
- GERE, A. R. (Ed.). (2019). DEVELOPING WRITERS IN HIGHER EDUCATION: A longitudinal study. S.l.: UNIV OF MICHIGAN PRESS. https://doi.org/10.3998/mpub.10079890
- Discipline:
- Humanities
-
- Creator:
- Danko, Melissa
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , capstone , sitesucker , website , and file directory
- Discipline:
- Humanities
-
- Creator:
- Danko, Melissa
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication: https://doi.org/10.3998/mpub.10079890), and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , gateway, sitesucker , website, and file directory
- Discipline:
- Humanities
-
- Creator:
- Mitchell, Michael
- Description:
- This eportfolio was created for the Gateway course of the Sweetland Minor in Writing to provide an opportunity for students to reflect on their growing identities as writers, as captured in their text-based and multimodal compositions produced over the Gateway semester. The title of the work contains the pseudonym created for the study while the creator field lists the student's given name to allow proper attribution for their work. The eportfolio is collected here as an artifact in the Sweetland Writing Development Study, which has been published as Developing Writers in Higher Education: A Longitudinal Study (University of Michigan Press, 2019). To learn more about this study, please see the epublication https://doi.org/10.3998/mpub.10079890, and to learn more about the Minor in Writing program and the eportfolio prompts, please see Appendix 2a ( https://doi.org/10.3998/mpub.10079890.cmp.1) to the publication.
- Keyword:
- eportfolio , gateway , sitesucker , website , and file directory
- Discipline:
- Humanities
-
- Creator:
- Thomaz, Andréa T. (UMICH), Carvalho, Tiago P. (UFRGS), Malabarba, Luiz R. (UFRGS), and Knowles, L. Lacey (UMICH)
- Description:
- Estimated phylogenetic relationships based on more than 18,000 loci in 93 individuals (full data) or 21 individuals (subset data) representing 19 described species and two putative undescribed species. Nine files are part of this dataset, including all input files to infer the phylogenetic reconstructions and the outputs obtained, in addition to a pruned tree used to infer the ancestral state reconstructions.
- Keyword:
- dusky millions poeciliids, sexual selection, South America, and ddRADseq
- Citation to related publication:
- Andréa T. Thomaz, Tiago P. Carvalho, Luiz R. Malabarba, L. Lacey Knowles, Geographic distributions, phenotypes, and phylogenetic relationships of Phalloceros (Cyprinodontiformes: Poeciliidae): insights about diversification among sympatric species pools, Molecular Phylogenetics and Evolution, 2018, ISSN 1055-7903, https://doi.org/10.1016/j.ympev.2018.12.008
- Discipline:
- Science
-
- Creator:
- Gharzai, Laila A, Green, Michael D, Griffith, Kent A, and Jolly, Shruti
- Description:
- Three sensitivity analyses were performed. First, a second matching step was performed in which two controls were selected for each case, where possible using a nearest neighbor and caliper metric. Controls needed to have propensity scores within 0.1 of the case to be selected. Thirty-eight of the 39 cases had at least one control using this method and for 36 cases two controls could be selected. The average difference between case and control propensity adjuvant RT was 0.008 (range 0.00003-0.095). A second sensitivity analysis was performed to guard against immortal time bias. In order to mitigate the possibility of this effect, cases known not to have undergone adjuvant RT have been screened for suitable follow-up without a recurrence (local or regional recurrence, metastatic failure, and/or death) to ensure that if adjuvant RT had been prescribed as part of the multi-modality treatment regimen, that it would have been initiated. Three months was selected as the mandatory follow-up time. One to one matching was carried out and all 39 cases were matched to a control. A third sensitivity analysis was performed to account for stage migration seen in control patients that presented to the University of Michigan with more advanced disease. Patients that underwent adjuvant radiation were matched one to one with control group patients who did not receive adjuvant radiation, and who had the same stage at diagnosis as compared to stage at University of Michigan presentation.
- Keyword:
- adenocortical carcinoma and English
- Discipline:
- Health Sciences
-
- Creator:
- Hatch, Nan E.
- Description:
- Craniosynostosis is the premature fusion of cranial bones. The goal of this study was to determine if delivery of recombinant tissue nonspecific alkaline phosphatase (TNAP) could prevent or diminish the severity of craniosynostosis in a C57BL/6 FGFR2C342Y/+ model of neonatal onset craniosynostosis or a BALB/c FGFR2C342Y/+ model of postnatal onset craniosynostosis. Mice were injected with a lentivirus encoding a mineral targeted form of TNAP immediately after birth. Cranial bone fusion as well as cranial bone volume, mineral content and density were assessed by micro computed tomography. Craniofacial shape was measured with calipers., Alkaline phosphatase, alanine amino transferase (ALT) and aspartate amino transferase (AST) activity levels were measured in serum. Neonatal delivery of TNAP diminished craniosynostosis severity from 94% suture obliteration in vehicle treated mice to 67% suture obliteration in treated mice, p<0.02) and the incidence of malocclusion from 82.4% to 34.7% (p<0.03), with no effect on cranial bone in C57BL/6 FGFR2C342Y/+ mice. In contrast, treatment with TNAP improved cranial bone volume (p< 0.01), density (p< 0.01) and mineral content (p< 0.01) but had no effect on craniosynostosis or malocclusion in BALB/c FGFR2C342Y/+ mice. , These results indicate that post-natal recombinant TNAP enzyme therapy diminishes craniosynostosis severity in the C57BL/6 FGFR2C342Y/+ neonatal onset mouse model of Crouzon syndrome, and that effects of exogenous TNAP are genetic background dependent., and Included in this collection is one set of images representing the C57BL/6 FGFR2C342Y/+ model of neonatal onset craniosynostosis, and one for the BALB/c FGFR2C342Y/+ model of postnatal onset craniosynostosis
- Keyword:
- craniofacial, bone, craniosynostosis, FGFR2, TNAP, mouse model, and development
- Discipline:
- Health Sciences
2Works