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- Creator:
- Skerlos, Steven J.
- Description:
- Supporting Information for research article "Life cycle comparison of environmental emissions from three disposal options for unused pharmaceutical". This spreadsheet provides the calculations and values used for this study; please refer to the manuscript and supporting information (as text) available at http://dx.doi.org/10.1021/es203987b for details about how to use this spreadsheet. We use life cycle assessment methodology to compare three disposal options for unused pharmaceuticals: (i) incineration after take-back to a pharmacy, (ii) wastewater treatment after toilet disposal, and (iii) landfilling or incineration after trash disposal. For each option, emissions of active pharmaceutical ingredients to the environment (API emissions) are estimated along with nine other types of emissions to air and water (non-API emissions). Under a scenario with 50% take-back to a pharmacy and 50% trash disposal, current API emissions are expected to be reduced by 93%. This is within 6% of a 100% trash disposal scenario, which achieves an 88% reduction. The 50% take-back scenario achieves a modest reduction in API emissions over a 100% trash scenario while increasing most non-API emissions by over 300%. If the 50% of unused pharmaceuticals not taken-back are toileted instead of trashed, all emissions increase relative to 100% trash disposal. Evidence suggests that 50% participation in take-back programs could be an upper bound. As a result, we recommend trash disposal for unused pharmaceuticals. A 100% trash disposal program would have similar API emissions to a take-back program with 50% participation, while also having significantly lower non-API emissions, lower financial costs, higher convenience, and higher compliance rates.
- Discipline:
- Engineering
-
- Creator:
- Dr. Francis C. Evans
- Description:
- The Evans Old Field Plant Database contains FileMaker and Excel files of data collected by Dr. Francis C. Evans during a 50-year study on successional change on Evans Old Field on the Edwin S. George Reserve. Data include plant phenology, location, and abundances observed from 1948 to 1997.
- Discipline:
- Science
-
- Creator:
- Zurbuchen, Thomas H.
- Description:
- Audification Routines in MATLAB and IDL
- Discipline:
- Science
-
- Creator:
- Keener, Alix
- Description:
- As discussion and debates on the digital humanities continue among scholars, so too does discussion about how academic libraries can and should support this scholarship. Through interviews with digital humanities scholars and academic librarians within the Center for Institutional Cooperation, this study aims to explore some points of common perspective and underlying tensions in research relationships. Qualitative interviews revealed that, while both groups are enthusiastic about the future of faculty-librarian collaboration on digital scholarship, there remain certain tensions about the role of the library and the librarian. Scholars appreciate the specialized expertise of librarians, especially in metadata and special collections, but they can take a more active stance in utilizing current library resources or vocalizing their needs for other resources. This expertise and these services can be leveraged to make the library an active and equal partner in research. Additionally, libraries should address internal issues, such as training and re-skilling librarians as necessary; better-coordinated outreach to academic departments is also needed.
- Discipline:
- Humanities
-
- Creator:
- University of Michigan Transportation Research Institute, Rupp, Jonathan D., Klein, Katelyn F., and Reed, Matthew P.
- Description:
- The files include an Excel file with the x-, y-, and z- coordinates that make up the nodal coordinates for a surface model of small (5th percentle) female pelvis geometry, the finite element model (.k file) that represents the nodal coordinates, and two surface files that represent the geometry (.obj and .ply).
- Discipline:
- Engineering
-
- Creator:
- Carson IV, William F.
- Description:
- Raw data and analysis files for the figures corresponding to the manuscript submission entitled "CCL2 enhances macrophage inflammatory responses via miR-9 mediated downregulation of the ERK1/2 phosphatase Dusp6"
- Discipline:
- Science
-
- Creator:
- Ozturk, Dogacan Su
- Description:
- The rapid increases in solar wind dynamic pressure, termed sudden impulses (SIs), compress Earth’s dayside magnetosphere and strongly perturb the coupled Magnetosphere-Ionosphere (M-I) system. The compression of the dayside magnetosphere launches magnetohydrodynamic (MHD) waves, which propagate down to the ionosphere, changing the Auroral Field Aligned Currents (FACs), and into nightside magnetosphere. The global response to the compression front sweeping through the coupled system is not yet fully understood due to the sparseness of the measurements, especially those with the necessary time resolution to resolve the propagating disturbances. That’s why a study including modeling is necessary. On 15 August 2015 at 7.44 UT, Advanced Composition Explorer measured a sudden increase in the solar wind dynamic pressure from 1.11 nPa to 2.55 nPa as shown in Figure-1. We use the magnetospheric spacecraft in the equatorial magnetosphere to identify the signatures of magnetosphere response to this SI event and examine the interaction of the propagating disturbances with the M-I system. With the increased time resolution of Active Magnetosphere and Polar Electrodynamics Response Experiment (AMPERE), the FAC pattern and intensity change due to SI can also be studied in more depth. We further use measurements from ground based magnetometer stations to increase our tracking capability for the disturbances in the ionosphere and to improve our understanding of their propagation characteristics. This is the first step in a comprehensive multi-point observation and a global magnetohydrodynamic simulation based investigation of the response of the coupled M-I system to sudden impulses.
- Discipline:
- Science
-
- Creator:
- Stoev, Stilian and Hu, Weifeng
- Description:
- Many data sets come as point patterns of the form (longitude, latitude, time, magnitude). The examples of data sets in this format includes tornado events, origins/destination of internet flows, earthquakes, terrorist attacks and etc. It is difficult to visualize the data with simple plotting. This research project studies and implements non-parametric kernel smoothing in Python as a way of visualizing the intensity of point patterns in space and time. A two-dimensional grid M with size mx, my is used to store the calculation result for the kernel smoothing of each grid points. The heat-map in Python then uses the grid to plot the resulting images on a map where the resolution is determined by mx and my. The resulting images also depend on a spatial and a temporal smoothing parameters, which control the resolution (smoothness) of the figure. The Python code is applied to visualize over 56,000 tornado landings in the continental U.S. from the period 1950 - 2014. The magnitudes of the tornado are based on Fujita scale.
- Discipline:
- Engineering and Science
-
- Creator:
- Heath, Jeffrey and Dicko, Adama
- Description:
- transcription/translation to appear
- Discipline:
- Humanities
-
- Creator:
- Heath, Jeffrey and Dicko, Adama
- Description:
- translation/transcription to appear
- Discipline:
- Humanities
-
- Creator:
- Heath, Jeffrey and Dicko, Adama
- Description:
- transcription/translation to appear.
- Discipline:
- Humanities
-
- Creator:
- Heath, Jeffrey and Dicko, Adama
- Description:
- translation/translation to appear.
- Discipline:
- Humanities
-
- Creator:
- Heath, Jeffrey and Dicko, Adama
- Description:
- transcriptions and translation to appear; second of two parts of this text
- Discipline:
- Humanities
-
- Creator:
- Grosh, Karl and Li, Yizeng
- Description:
- In a sensitive cochlea, the basilar membrane response to transient excitation of any kind--normal acoustic or artificial intracochlear excitation--consists of not only a primary impulse but also a coda of delayed secondary responses with varying amplitudes but similar spectral content around the characteristic frequency of the measurement location. The coda, sometimes referred to as echoes or ringing, has been described as a form of local, short term memory which may influence the ability of the auditory system to detect gaps in an acoustic stimulus such as speech. Depending on the individual cochlea, the temporal gap between the primary impulse and the following coda ranges from once to thrice the group delay of the primary impulse (the group delay of the primary impulse is on the order of a few hundred microseconds). The coda is physiologically vulnerable, disappearing when the cochlea is compromised even slightly. The multicomponent sensitive response is not yet completely understood. We use a physiologically-based, mathematical model to investigate (i) the generation of the primary impulse response and the dependence of the group delay on the various stimulation methods, (ii) the effect of spatial perturbations in the properties of mechanically sensitive ion channels on the generation and separation of delayed secondary responses. The model suggests that the presence of the secondary responses depends on the wavenumber content of a perturbation and the activity level of the cochlea. In addition, the model shows that the varying temporal gaps between adjacent coda seen in experiments depend on the individual profiles of perturbations. Implications for non-invasive cochlear diagnosis are also discussed.
- Discipline:
- Engineering and Health Sciences
-
- Creator:
- Atwell, Jon
- Description:
- The data file is json formatted and all fields are named descriptively. The code is written in Python 2.7 and is heavily commented.
- Keyword:
- inequality and coadaptation
- Discipline:
- Social Sciences and Science
-
- Creator:
- Ottaviani, Jim
- Description:
- This random sample of OA articles comes from Deep Blue <deepblue.lib.umich.edu/documents>, the University of Michigan’s institutional repository service. Each OA article has the following characteristics: Prior to a known date (ranging from 2006 to the 2013) these articles—the final published version—were only available by subscription. After that date, they became freely available via Deep Blue. Meanwhile, other articles from the same journal issue as the now-OA article continued to only be available to subscribers. None of the OA articles were self-selected; authors did not choose to deposit the articles in question in Deep Blue, since we made them open via blanket licensing agreements between the publishers and the library.
- Keyword:
- Open access publishing, Scientific publishing, Citation analysis, and Institutional repositories
- Discipline:
- Social Sciences
-
- Creator:
- Wen, Ai, Foxman. Betsy, Srinivasan, Usha , Goldberg, Deborah , Marrs, Carl F , Owen, John, Wing, Deborah A., Misra, Dawn , Cronenwett, Anna , Ponnaluri, Sreelatha, Miles-Jay, Arianna, Bucholz, Brigette, and Abbas, Khadija
- Description:
- This is the bacterial DNA data extracted from the gram stain slides. The targeted bacteria genera and species include: Atopobium spp., bacterial vaginosis-associated bacterium (BVAB) types 1, 2 and 3 in the order Clostridiales, Escherichia coli, Gardnerella vaginalis, Group B Streptococcus, Lactobacillus spp., Mobiluncus spp., Mycoplasma spp., and Ureaplasma spp. We also used a primer set for Lactic Acid Bacteria (LAB) that includes lactic acid producing bacteria of the genera Lactobacillus, Pediococcus, Leuconostoc, and Weissella. We calculated the relative proportion of each bacterial taxon using the bacterial copies measured by each specific bacteria primer divided by the total bacterial copies. The limit of detection was 100 copies and readings lower than the limit were considered negative
- Citation to related publication:
- Wen A, Srinivasan U, Goldberg D, Owen J, Marrs CF, Misra D, Wing DA, Ponnaluri S, Miles-Jay A, Bucholz B, Abbas K, Foxman B. Selected vaginal bacteria and risk of preterm birth: an ecological perspective. J Infect Dis. 2014 Apr 1;209(7):1087-94. https://doi.org/10.1093/infdis/jit632. Epub 2013 Nov 22. PMID: 24273044; PMCID: PMC3952673. and Foxman B, Wen A, Srinivasan U, Goldberg D, Marrs CF, Owen J, Wing DA, Misra D. Mycoplasma, bacterial vaginosis-associated bacteria BVAB3, race, and risk of preterm birth in a high-risk cohort. Am J Obstet Gynecol. 2014 Mar;210(3):226.e1-7. https://doi.org/10.1016/j.ajog.2013.10.003. Epub 2013 Oct 4. PMID: 24096128; PMCID: PMC3943817.
- Discipline:
- Health Sciences
-
- Creator:
- Meurer, William J., Meka, Arjun, and Porath, Jon
- Description:
- Introduction: Diagnostic testing is common in the emergency department. The value of some testing is questionable. The purpose of this study was to assess how varying levels of benefit, risk, and costs influenced an individual’s desire to have diagnostic testing. Methods: A survey through Amazon Mechanical Turk presented hypothetical clinical situations: low risk chest pain and minor traumatic brain injury. Each scenario included three given variables (benefit, risk, and cost), that was independently randomly varied over four possible values (0.1%, 1%, 5%, 10% for benefit and risk and $0, $100, $500, and $1000 for the individual’s personal cost for receiving the test). Benefit was defined as the probability of finding the target disease (traumatic intracranial hemorrhage or acute coronary syndrome). Results: A total of 1000 unique respondents completed the survey. Increasing benefit from 0.1% to 10%, the percent of respondents who accepted a diagnostic test went from 28.4% to 53.1%. [OR: 3.42 (2.57-4.54)] As risk increased from 0.1% to 10%, this number decreased from 52.5% to 28.5%. [OR: 0.33 (0.25-0.44)] Increasing cost from $0 to $1000 had the greatest change of those accepting the test from 61.1% to 21.4%, respectively. [OR: 0.15 (0.11-0.2)] Conclusions: The desire for testing was strongly sensitive to the benefits, risks and costs. Many participants wanted a test when there was no added cost, regardless of benefit or risk levels, but far fewer elected to receive the test as cost increased incrementally. This suggests that out of pocket costs may deter patients from undergoing diagnostic testing with low potential benefit.
- Discipline:
- Health Sciences
-
- Creator:
- Carson, William F. IV
- Description:
- Data files pertaining to the manuscript entitled: "THE STAT4/MLL1 EPIGENETIC AXIS REGULATES THE ANTIMICROBIAL FUNCTIONS OF MURINE MACROPHAGES"
- Discipline:
- Health Sciences
-
- Creator:
- Carson, William F., IV
- Description:
- Transcriptional accessibility of chromatin is central to guiding CD4+ T cell function through regulation of lineage specific gene expression. Myst1 is a histone acetyltransferase responsible for acetylation of the protein tail of histone 4 at lysine residue 16 (H416ac), resulting in increased transcriptional accessibility and activation of gene transcription. Previous studies have described a role for Myst1 in governing lymphocyte development in the thymus, however the role of Myst1 and H4K16ac in guiding activation of peripheral CD4+ T cells has not been studied. Activation of human and murine CD4+ T cells resulted in upregulation of Myst1 expression, and deletion of Myst1 resulted in changes in proliferative responses to both polyclonal stimulus and exogenous cytokines. Myst1-deficient T cells also exhibited modulations in lineage commitment, with decreased function in TH1/TH2 skewing conditions and increased function in response to TH17-promoting conditions. Regulation of Myst1 function in CD4+ T cells appears governed at least in part by STAT5, as Myst1 expression is regulated by STAT5 expression and DNA binding, and modulations in H4K16ac in Myst1-deficient CD4+ T cells is observable at sites in the promoter regions of lineage specific genes following skewing to the TH1 or TH2 lineage in vitro. Taken together, these results indicate an important role for the STAT5-Myst1 epigenetic axis in governing the activation and effector function of CD4+ T cells.
- Discipline:
- Science
-
- Creator:
- Meurer, William
- Description:
- Dataset for analysis in SPSS
- Discipline:
- Health Sciences
-
- Creator:
- Sifuentes, Christopher J
- Description:
- Differential expression data from zebrafish regeneration and mouse degeneration models.
- Keyword:
- regeneration, stem cells, photoreceptor, zebrafish, and Müller glia
- Citation to related publication:
- Sifuentes, C. J. (2016). Regulation of Müller glial stem cell properties: Insights from a zebrafish model (Doctoral dissertation). Retrieved from http://hdl.handle.net/2027.42/135939
- Discipline:
- Science
-
- Creator:
- Sifuentes, Christopher J
- Description:
- Gene ontology data from zebrafish regeneration and mouse degeneration models.
- Keyword:
- Müller glia, stem cells, photoreceptors, zebrafish, and regeneration
- Citation to related publication:
- Sifuentes, C. J. (2016). Regulation of Müller glial stem cell properties: Insights from a zebrafish model (Doctoral dissertation). Retrieved from http://hdl.handle.net/2027.42/135939
- Discipline:
- Science
-
- Creator:
- Sifuentes, Christopher J
- Description:
- Pathway data for zebrafish regeneration and mouse degeneration models.
- Keyword:
- regeneration, stem cells, photoreceptor, zebrafish, and Müller glia
- Citation to related publication:
- Sifuentes, C. J. (2016). Regulation of Müller glial stem cell properties: Insights from a zebrafish model (Doctoral dissertation). Retrieved from http://hdl.handle.net/2027.42/135939
- Discipline:
- Science
-
- Creator:
- Sifuentes, Christopher J
- Description:
- Differential expression data and genes in linked peaks in mi2004 mutants.
- Keyword:
- Müller glia, stem cells, photoreceptor, zebrafish, and regeneration
- Citation to related publication:
- Sifuentes, C. J. (2016). Regulation of Müller glial stem cell properties: Insights from a zebrafish model (Doctoral dissertation). Retrieved from http://hdl.handle.net/2027.42/135939
- Discipline:
- Science
-
- Creator:
- Sifuentes, Christopher J
- Description:
- Gene ontology data from mi2004 mutants
- Keyword:
- Müller glia, stem cells, photoreceptor, zebrafish, and regeneration
- Citation to related publication:
- Sifuentes, C. J. (2016). Regulation of Müller glial stem cell properties: Insights from a zebrafish model (Doctoral dissertation). Retrieved from http://hdl.handle.net/2027.42/135939
- Discipline:
- Science
-
- Creator:
- Sifuentes, Christopher J
- Description:
- Pathway data from mi2004 mutants.
- Keyword:
- Müller glia, stem cells, photoreceptor, zebrafish, and regeneration
- Citation to related publication:
- Sifuentes, C. J. (2016). Regulation of Müller glial stem cell properties: Insights from a zebrafish model (Doctoral dissertation). Retrieved from http://hdl.handle.net/2027.42/135939
- Discipline:
- Science
-
- Creator:
- Sifuentes, Christopher J
- Description:
- Linkage plots and data for mi2004 mutants.
- Keyword:
- Müller glia, stem cells, photoreceptor, zebrafish, and regeneration
- Citation to related publication:
- Sifuentes, C. J. (2016). Regulation of Müller glial stem cell properties: Insights from a zebrafish model (Doctoral dissertation). Retrieved from http://hdl.handle.net/2027.42/135939
- Discipline:
- Science
-
- Creator:
- Sifuentes, Christopher J
- Description:
- Inverse PCR and genome-walking data.
- Keyword:
- regeneration, stem cells, photoreceptor, zebrafish, and Müller glia
- Citation to related publication:
- Sifuentes, C. J. (2016). Regulation of Müller glial stem cell properties: Insights from a zebrafish model (Doctoral dissertation). Retrieved from http://hdl.handle.net/2027.42/135939
- Discipline:
- Science
-
- Creator:
- Data-Driven Detroit, Goodspeed, Robert, Reference U.S.A., Veinot, Tiffany C., Yan, Xiang, State of Michigan Department of Elections, and Okullo, Dolorence
- Description:
- The Social Environment refers to characteristics of the people and institutions in a census tract, including: 1) Religious organizations (churches and places of worship); and 2) Voter turnout for the 2012 Presidential Election. Coverage for all data: 10-county Detroit-Warren-Ann Arbor Combined Statistical Area.
- Keyword:
- Voter Turnout, Religious Institutions, Spatial Measures, and Census Tract Level
- Discipline:
- Health Sciences and Social Sciences
-
- Creator:
- Reference USA, City of Detroit, ESRI, Data Driven Detroit, and Veinot, Tiffany C.
- Description:
- Active living resources include spaces and organizations that facilitate physical activity, including 1) park land, 2) recreation areas (including parks, golf courses, amusement parks, beaches and other recreational landmarks); and 3) recreation centers (including gyms, dancing instruction, martial arts instruction, bowling centers, yoga instruction, sports clubs, fitness programs, golf course, pilates instruction, personal trainers, swimming pools, skating rinks, etc.) Coverage for all data: 10-county Detroit-Warren-Ann Arbor Combined Statistical Area.
- Keyword:
- Recreation Areas, Park Land, Census tract level, Metropolitan Detroit, Spatial Measures, Recreation Centers, and Michigan
- Discipline:
- Health Sciences, Social Sciences, and Other
-
- Creator:
- Wellman, Michael P.
- Description:
- For each game: - file in JSON format with raw payoff data - text file with game-theoretic analysis results
- Discipline:
- Social Sciences
-
- Creator:
- Shtull-Leber, Eytan
- Description:
- We present the SAS code used to conduct the data manipulation and analysis for our research on pre-hospital midazolam use before and after RAMPART.
- Keyword:
- emergency medical services, knowledge translation, status epilepticus, benzodiazepines, midazolam, EMS, and Seizure
- Discipline:
- Health Sciences
-
- Creator:
- Tsai, Grace and Kuipers, Benjamin
- Description:
- ******Michigan Indoor Corridor 2012 Dataset****** This dataset is made available for research purpose only. Please contact Grace Tsai( gstsai@umich.edu) for any questions or comments. This dataset was used to produce the results in our IROS 2012 paper. If you use the data, please cite the following reference in your publications related to this work: Grace Tsai and Benjamin Kuipers Dynamic Visual Understanding of the Local Environment for an Indoor Navigating Robot International Conference on Intelligent Robots and Systems (IROS'12) October 2012 The dataset contains 4 video sequences acquired with camera mounted on a wheeled vehicle. The camera was set-up so that there was zero tilt and roll angle with respect to the ground. The camera has a fixed height (0.47 m) with the ground throughout the video. The intrinsic parameters of the cameras are: Focal length fc = [ 1389.182714 1394.598277 ] Principal point cc = [ 672.605430 387.235803 ] The distortion of the camera has been corrected. For each video sequences, an estimated camera pose in each frame of the video is provided in the file pose.txt. Each line in the file looks like: <frame index> <x (pose)> <y (pose)> <theta (pose)> Note the camera poses provided here are estimated by using an occupancy grid mapping algorithm with a laser range finder to obtain the robot pose. The dataset provides a ground truth labeling for all the pixels every 10 frames for each video. The labels of each frame is stored as a 2D matrix in a .mat file. The filename of each .mat file corresponds to the image frame. The labels can be interpreted as followed: -2 -> ceiling plane -1 -> ground plane >0 -> walls The labels of the walls are illustrated in a .pdf figure. Note the figure is only a illustration graph, not an actual floor plan.
- Keyword:
- Robotics and Computer vision
- Discipline:
- Engineering
-
- Creator:
- Figueroa, C. Alberto
- Description:
- Magnetic resonance angiography (MRA) of the aorta of a 30 yo healthy volunteer, segmented and discretized using the software CRIMSON ( www.crimson.software). Additionally, models corresponding to virtually-aged aortic geometries at ages: 40, 60, and 75.
- Keyword:
- Pulse Wave Velocity, Blood flow modeling, Hypertension, and Aging
- Discipline:
- Engineering
-
- Creator:
- Yang, Bing and Wittkopp, Patricia J
- Description:
- Datafiles and code described in accompanying MS, currently in review
- Keyword:
- regulatory network evolution
- Discipline:
- Science
-
- Creator:
- Title, Pascal O. and Bemmels, Jordan B.
- Description:
- The ENVIREM dataset v1.0 is a set of 16 climatic and 2 topographic variables that can be used in modeling species' distributions. The strengths of this dataset include their close ties to ecological processes, and their availability at a global scale, at several spatial resolutions, and for several time periods. The underlying temperature and precipitation data that went into their construction comes from the WorldClim dataset ( www.worldclim.org), and the solar radiation data comes from the Consortium for Spatial Information ( www.cgiar-csi.org). The data are compatible with and expand the set of variables from WorldClim v1.4 ( www.worldclim.org). For more information, please visit the project website: envirem.github.io
- Keyword:
- raster, species distribution modeling, and bioclimatic
- Citation to related publication:
- Title, P. O. and Bemmels, J. B. (2018), ENVIREM: an expanded set of bioclimatic and topographic variables increases flexibility and improves performance of ecological niche modeling. Ecography, 41: 291-307. http://doi.org/10.1111/ecog.02880
- Discipline:
- Science
-
- Creator:
- Meurer, William
- Description:
- Full analytical dataset with labels in SPSS
- Keyword:
- Diagnostic testing
- Discipline:
- Health Sciences
-
- Creator:
- Okullo, Dolorence, Yan, Xiang (Jacob), Data Driven Detroit, Veinot, Tiffany C., Gomez-Lopez, Iris N., and Goodspeed, Robert
- Description:
- The food environment is: 1) The physical presence of food that affects a person’s diet; 2) A person’s proximity to food store locations; 3) The distribution of food stores, food service, and any physical entity by which food may be obtained; or 4) A connected system that allows access to food. (Source: https://www.cdc.gov/healthyplaces/healthtopics/healthyfood/general.htm) Data included here concern: 1) Food access; and 2) Liquor access. Spatial Coverage for most data: 10-county Detroit-Warren-Ann Arbor Combined Statistical Area, Michigan, USA. See exception for grocery store data below.
- Keyword:
- Food Deserts, Census tract level, Full-Line Grocery Stores, Modified Retail Food Environment Index (MRFEI), Farmer’s Markets, Spatial Measures, and Fast Food Establishments
- Discipline:
- Social Sciences, Health Sciences, and Other
-
- Creator:
- Yoshida, Sei and Swanson, Joel A
- Description:
- The rapid activation of the mechanistic target of rapamycin complex-1 (mTORC1) by growth factors is increased by extracellular amino acids through yet-undefined mechanisms of amino acid transfer into endolysosomes. Because the endocytic process of macropinocytosis concentrates extracellular solutes into endolysosomes and is increased in cells stimulated by growth factors or tumor-promoting phorbol esters, we analyzed its role in amino acid–dependent activation of mTORC1. Here, we show that growth factor-dependent activation of mTORC1 by amino acids, but not glucose, requires macropinocytosis. In murine bone marrow–derived macrophages and murine embryonic fibroblasts stimulated with their cognate growth factors or with phorbol myristate acetate, activation of mTORC1 required an Akt-independent vesicular pathway of amino acid delivery into endolysosomes, mediated by the actin cytoskeleton. Macropinocytosis delivered small, fluorescent fluid-phase solutes into endolysosomes sufficiently fast to explain growth factor–mediated signaling by amino acids. Therefore, the amino acid–laden macropinosome is an essential and discrete unit of growth factor receptor signaling to mTORC1
- Keyword:
- growth factor signaling, Macropinosomes, and mTORC1
- Discipline:
- Health Sciences
-
- Creator:
- Larson, Ronald G., Wen, Fei, Huang, Wenjun, and Huang, Ming
- Description:
- We provide the parameters used in Umbrella Sampling simulations reported in our study "Efficient Estimation of Binding Free Energies between Peptides and an MHC Class II Molecule Using Coarse-Grained Molecular Dynamics Simulations with a Weighted Histogram Analysis Method", namely the set positions and spring constants for each window in simulations. Two tables are provided. Table 1 lists the names of the peptides and their corresponding sequences. Table 2 lists the parameters. The abstract of our work is the following: We estimate the binding free energy between peptides and an MHC class II molecule using molecular dynamics (MD) simulations with Weighted Histogram Analysis Method (WHAM). We show that, owing to its more thorough sampling in the available computational time, the binding free energy obtained by pulling the whole peptide using a coarse-grained (CG) force field (MARTINI) is less prone to significant error induced by biased-sampling than using an atomistic force field (AMBER). We further demonstrate that using CG MD to pull 3-4 residue peptide segments while leaving the remain-ing peptide segments in the binding groove and adding up the binding free energies of all peptide segments gives robust binding free energy estimations, which are in good agreement with the experimentally measured binding affinities for the peptide sequences studied. Our approach thus provides a promising and computationally efficient way to rapidly and relia-bly estimate the binding free energy between an arbitrary peptide and an MHC class II molecule.
- Keyword:
- Molecular Dynamics, Binding Free Energy, Protein, MHC, and Coarse-Grained
- Discipline:
- Science and Engineering
-
- Creator:
- Okullo, Dolorence, Gomez-Lopez, Iris N., Goodspeed, Robert, Reddy, Shruthi, Veinot, Tiffany C, Clarke, Phillipa J., and Data Driven Detroit
- Description:
- The information and education environment refers to: 1) the presence of information infrastructures such as broadband Internet access and public libraries in a location; 2) a person’s proximity to information infrastructures and sources; 3) the distribution of information infrastructures, sources and in a specific location; and 4) exposure to specific messages (information content) within a specific location. Coverage for all data: 10-county Detroit-Warren-Ann Arbor Combined Statistical Area.
- Keyword:
- Residential Broadband Data Adoption Rates, Census tract level, Broadband Internet Access and Speed, Colleges and Universities, Public Libraries, Spatial Measures, and Schools
- Discipline:
- Science, Social Sciences, and Health Sciences
-
- Creator:
- Jones, Monica L.H.
- Description:
- This study evaluated the performance of a video-based intervention for improving the belt fit obtained by drivers. Previous laboratory studies have demonstrated that some drivers position their seat belts suboptimally. Specifically, the lap portion of the belt may be higher and farther forward relative to the pelvis than best practice, and the shoulder portion of the belt may be outboard or inboard of mid-shoulder. A video was developed to present the most important aspects of belt fit best practices, with emphasis on the lap belt. The video demonstrated how a seat belt should be routed with respect to an individual’s anatomy to ensure a proper fit. The three key belt fit concepts conveyed in the video were: 1) Lap belt low on hips, touching the thighs. 2) Shoulder belt crossing middle of collarbone. 3) Belt snug, as close to bones as possible. Additional context about the ability to achieve to good belt fit, such as opening a heavy coat or adjusting the height adjusters on the B-pillar behind the windows, were also presented.
- Keyword:
- Safety, Seatbelt Fit, Intervention, and Evaluation
- Discipline:
- Engineering
-
- Creator:
- Jones, Monica L.H.
- Description:
- These manikins represent body shape models for children weighing 9 to 23 kg in a seated posture relevant to child restraint design. The design of child restraints is guided in part by anthropometric data describing the distributions of body dimensions of children. However, three-dimensional body shape data have not been available for children younger than three years of age. These manikins will be useful for assessing child accommodation in restraints. The SBSM can also provide guidance for the development of anthropomorphic test devices and computational models of child occupants. The sampled manikins were predicted for a range of torso length and body weight dimensions. The SBSM model was exercised for two torso lengths and nine body weights to obtain 18 body shapes. The 3D shape models can be downloaded in a standard mesh format (PLY). Each body shape is accompanied by predicted landmark locations and standard anthropometric variables.
- Keyword:
- Child anthropometry, Child restraint system, Statistical body shape model, and Anthropomorphic testing device (ATD)
- Discipline:
- Engineering
-
- Creator:
- Grosky, William I. and Ruas, Terry L.
- Description:
- This dataset was used for a proof-of-concept of fixed lexical chain approach for semantic information retrieval.
- Keyword:
- fixed lexical chains
- Discipline:
- Engineering
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- Creator:
- Steiner, A.L. and Kawecki, S.
- Description:
- Kansas City, MO emissions can affect a severe weather system by altering the number of CCN, which drives changes in the hydrometeor development. The hydrometeor changes affect cold pool strength, size, and propagation which ultimately determine the strength of the squall line that crosses Kansas City, MO.
- Keyword:
- Great Plains, aerosols, mesoscale convective systems, and weather
- Discipline:
- Science
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- Creator:
- Engel, Michael, Glotzer, Sharon C., Anderson, Joshua A., Antonaglia, James, and Millan, Jaime A.
- Description:
- This dataset was generated for our work "Shape and symmetry determine two-dimensional melting transitions of hard regular polygons". The dataset includes simulation results for 13 different polygons (equilateral triangles through regular tetradecagons and the 4-fold pentille) at a variety of packing fractions near the isotropic fluid to solid phase transition. Each trajectory contains the final 4 frames of each simulation run we conducted at system sizes of over one million particles. For each shape, there is a JSON file that describes the vertices of the polygon and a number of simulation trajectory files in GSD ( https://bitbucket.org/glotzer/gsd) format. The trajectory files contain the positions and orientations of all the polygons at each frame, along with the simulation box size. The trajectory file names identify the packing fraction of that simulation run.
- Discipline:
- Engineering
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- Creator:
- James, David A.
- Description:
- An Excel spreadsheet listing the information recorded on each of 18,686 costume designs can be viewed, downloaded, and explored. All the usual Excel sorting possibilities are available, and in addition a useful filter has been installed. For example, to find the number of designs that are Frieze Type #1, go to the top of the frieze type 2 column (column AS), click on the drop-down arrow and unselect every option box except True (i.e. True should be turned on, all other choices turned off). Then in the lower left corner, one reads “1111 of 18686 records found”. Much more sophisticated exploration can be carried out by downloading the rich and flexible Access Database. The terms used for this database were described in detail in three sections of Deep Blue paper associated with this project. The database can be downloaded and explored. HOW TO USE THE ACCESS DATABASE 1. Click on the Create Cohort and View Math Trait Data button, and select your cohort by clicking on the features of interest (for example: Apron and Blouse). Note: Depending on how you exited on your previous visit to the database, there may be items to clear up before creating the cohorts. a) (Usually unnecessary) Click on the small box near the top left corner to allow connection to Access. b) (Usually unnecessary) If an undesired window blocks part of the screen, click near the top of this window to minimize it. c) Make certain under Further Filtering that all four Exclude boxes are checked to get rid of stripes and circles, and circular buttons, and the D1 that is trivially associated with shoes. 2. Click on Filter Records to Form the Cohort button. Note the # of designs, # of pieces, and # of costumes beside Recalculate. 3. Click on Calculate Average Math Trait Frequency of Cohort button, and select the symmetry types of interest (for example: D1 and D2) . 4. To view the Stage 1 table, click on Create Stage 1 table. To edit and print this table, click on Create Excel (after table has been created). The same process works for Stages 2, 3.and 4 tables. 5. To view the matrix listing the math category impact numbers, move over to a button on the right side and click on View Matrix of Math Category Impact Numbers. To edit and print this matrix, click on Create Excel, use the Excel table as usual.
- Keyword:
- Group Theory, European regional costume, Symmetry, Ethnomathematics, European folk costume, and Classification of designs
- Discipline:
- Other
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- Creator:
- Keppel-Aleks, Gretchen and Liptak, Jessica
- Description:
- -CESM_bdrd _NEP_pulse_response_CO2.nc contains time series from the ‘FullyCoupled’ simulation -CESM_bdrcs_NEP_pulse_response_CO2.nc contains time series from the ‘NoRad’ simulation -CESM_bdrd_pftcon_NEP_pulse_response_CO2.nc contains data from the ‘NoLUC’ simulation -CESM_bdrd_Regional_Fluxes_NEP.nc contains NEP time series for each terrestrial source region from the FullyCoupled simulation - CESM_bdrcs_Regional_Fluxes_NEP.nc contains NEP time series for each terrestrial source region from the CESM ‘NoRad’ simulation - CESM_bdrd_pftcon_Regional_Fluxes_NEP.nc contains NEP time series for each terrestrial source region from the CESM ‘NoLUC’ simulation The 3-letter station IDs, latitudes, and longitudes of the sample locations are: ID Latitude (ºN) Longitude (ºE) 1. BRW 71.3 203.4 2. ZEP 78.9 11.9 3. SHM 52.7 174.1 4. THD 41.1 235.8 5. TAP 36.7 126.1 6. BMW 32.3 295.1 7. MLO 19.5 204.4 8. POCN15 15.0 215.0 9. ALT 82.5 297.5 10. BHD -41.4 174.9 11. EIC -27.2 250.6 12. GMI 13.4 144.7 13. HUN 47.0 16.7 14. IZO 28.3 343.5 15. LLN 23.5 120.9 16. NAT -5.8 324.7 17. WLG 36.3 100.9 18. HBA -75.6 333.8 19. BKT -0.20 100.3 20. UUM 44.5 111.1 21. CGO -40.7 144.5 22. SDZ 40.7 117.1 23. ASC -8.0 345.6 24. SEY -4.7 55.5 25. POCS20 -20.0 186.0 26. POCS35 -35.0 180.0 27. PSA -64.9 296.0 28. SYO -69.0 39.6 29. CHR 1.7 202.8 30. KEY 25.7 279.8 31. BAL 55.4 17.2 32. HPB 47.8 11.0 33. LMP 35.5 12.6 34. NMB -23.6 15.0 35. RPB 13.2 300.2 36. WIS 30.0 35.1 37. POCS10 -10.0 199.0 38. POCN10 10.0 211.0 39. MID 28.2 182.6 40. SMO -14.2 189.4 41. SPO -90.0 335.2 The terrestrial CO2 source region abbreviations are: 1. NBNA 2. SBNA 3. ETNA 4. WTNA 5. CNAM 6. AMZN 7. EASA 8. WESA 9. EURO 10. SAME 11. MDAF 12. AFRF 13. SOAF 14. EABA 15. WEBA 16. SOBA 17. CNAS 18. SEAS 19. EQAS 20. AUST 21. GNLD 22. ATCA
- Keyword:
- atmospheric CO2 annual cycle amplitude and CESM extended concentration pathway
- Discipline:
- Science
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- Creator:
- Rowe, Mark D.
- Description:
- Animation files show the 12-month “baseline” simulations for 2000, 2005, and 2010 (see Table 1 of the paper cited above). temp_1_animation.wmv: Surface temperature Chl_1_animation.wmv: Surface chlorophyll-a PO4_1_animation.wmv: Surface total dissolved phosphorus Detritus_1_animation.wmv: Surface detritus concentration (particulate organic carbon, excluding phytoplankton and zooplankton). Zooplankton_1_animation.wmv: Surface zooplankton carbon concentration MRATION_1_animation.wmv: Rate of food assimilated by mussels, according to the product f_a F_A P in Equation 2, expressed as mg phytoplankton carbon per mg mussel biomass carbon per day × 100%. BIO_M_1_animation.wmv: Simulated mussel biomass in mg ash-free-dry-mass m^-2
- Keyword:
- Zooplankton, Model, Hydrodynamic model, Dreissenid mussels, Quagga mussel, Phytoplankton, and Lake Michigan
- Discipline:
- Science